While the majority of the proposed indicators have some validity, there are significant challenges in refining the current indicators and methodologies in a number of ways.
The proposed SPH methodology is used in a number of numerical examples involving composite materials and related interface problems.
This newly developed synthetic methodology is ideal in a number of ways as it can be easily altered to yield a high-quality product on a gram scale with low loss, is highly reproducible, and is based on green chemistry.
Their methodology was replicated in a number of subsequent studies that built similar databases for other languages, e.g., Spanish (Redondo et al. 2007) and French (Monnier and Syssau 2014).
The design methodology, as demonstrated in a number of development steps, and architecture are capable of handling various urban scenarios, as demonstrated in a June 2007 site visit by Darpa officials.
The proposed methodology is tested in a number of virtual scenarios within the CAD environment, and is implemented as a computer program referred to in this paper as FRAMEX, a tool developed using Visual Basic for Applications (VBA) as an add-on to AutoCAD.
It is informative to compare both of these studies to a series of investigations by a group working at Queen's University, Belfast, who also used CPRD to investigate the effects of β-blocker usage on mortality from breast, 27 colon 38 and prostate cancer 39 by using a methodology that differed in a number of respects.
Various molecular techniques, including conventional sequencing, pyrosequencing, real-time PCR and reverse hybridization assays with DNA probes have been proposed recently for detection of mutations associated with drug resistance with the latter methodology successfully realised in a number of in-house and commercial assays [ 8- 11].
Following our initial findings in urology, we extended the methodology to a number of other specialties to assess whether our findings in urology could be generalised to other surgical disciplines.
This methodology had been validated in a number of previous studies.
