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However, the application of the proposed methodology has required two kinds of surveys: a survey of passenger flows for estimating travel demand and a survey of boarding/alighting flows and train stop durations for determining the passenger flow dwell time function.
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But the ONS warns that there are "significant limitations" in this methodology, which has required "a number of assumptions", such as that there are the same number of prostitutes per male head of the population in London as the rest of the UK and that their services are not used at all by tourists.
Even defining what "exposed" means has required rigorous new methodology.
This departure has required the creation of new methodologies.
Development of the Directory within the lifecycle of the project has required rapid prototyping and agile methodologies, as discussed in [ 61].
This has required each approach to acknowledge or incorporate elements drawn from other methodologies and, accordingly, to soften its claims to methodological supremacy.
Qualitative and quantitative research is grounded in different methodological paradigms and reviewing qualitative studies would have required a different methodology.
Outcomes in addition to diagnostic accuracy, however, could not be systematically addressed in this review as they would have required a different methodology.
Adverse reactions and their impact on treatment completion could not be systematically addressed in our overview as this would have required a different methodology.
It would have been of interest to have measured the change in Zn status, as green leafy vegetables are a source of this mineral, but circulating Zn concentrations are tightly regulated, and this would have required a different methodology which was not feasible within the present study.
Due to the broad availability of MALDI mass spectrometers and the relatively simple sample preparation required, the methodology has been intensively developed in drug distribution analyses [11].
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CEO of Professional Science Editing for Scientists @ prosciediting.com