Exact(1)
(The Adizes methodology has addressed this problem successfully.(1)).
Similar(7)
Conventional risk assessment methodology, when it has addressed this issue at all, has relied on simplifying assumptions, both implicit and explicit, about combined effects from exposure to environmental mixtures.
The methodology described in the present work has addressed all these limitations.
Because no previous study has addressed the same issue using our methodology, we consider the present analyses as a first, hypothesis-generating study.
During this period, EFSA has addressed some of the concerns that applicants have conveyed to them about the proposed methodology, but several of the most fundamental concerns have not been addressed and are present in the paper under discussion.
Moreover, concerning the methodology, most epigenetic studies have addressed the effects of ART stressors on DNA methylation at the individual gene level and often analyze one or few CpG.
For these reasons our inclusion criteria required that the methodology employed by the authors had addressed at least one (ideally more) of the estimation challenges mentioned earlier.
A number of publications have addressed possible methodologies for quantifying sources of variability specific to given occupational settings (Kromhout et al. 1993; Peretz 2002; Preisser et al. 2003; Rappaport 1995), many of which deal directly or indirectly with exposure assessment and/or other applications relevant to studying pesticides and associated exposures or morbidity.
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