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Calling originalism a form of "activism masquerading as restraint," he says that the methodology "fails to constrain judicial choices" when the historical evidence is ambiguous, which it is in every hard case.
The cases where the former methodology fails to provide a valid reduced model, while the latter one succeeds, are explored.
If a methodology fails to have a prediction for a gene-TF pair, it is excluded in the above calculation.
This methodology fails to account however for the length of the individuals' neck, which need also be taken into consideration as this clearly influences the actual torque generated.
Consequently, our methodology fails to identify histocompatibility genes HLA-DQB1 and HLA-DRB1 as causative genes for the disease and may find other phenotypes arising from heterogeneous causes challenging (Supplementary Fig. 3c).
This suggests that the PD model may lack sufficient mechanistic detail to make in vitro– in vivo extrapolation of the IC50 appropriate or that the in vitro methodology fails to reflect the in vivo situation.
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Unsurprisingly, in view of its ubiquitously low expression levels, the methodology failed to identify PR1.
When compared to previously identified edit sites (PIES), this methodology failed to recognize 95 PIES but found 119 potential new sites.
When this happens, risk communication methodologies fail to achieve authentic dialogue and can exacerbate conflict.
Research in energy policy is complex and often involves inter-disciplinary work, which traditional economic methodologies fail to capture.
While many studies have considered this question, commonly employed methodologies fail to address the unique statistical challenge of modeling modes with small mode shares.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com