The performed experiments have also shown that an ordinary computer is capable of performing the proposed methodology, without any restriction.
Given that the FREEDOMS trials were not sufficiently similar to the DEFINE, CONFIRM and TEMSO trials, use of the Bucher methodology without any adaptation may not have provided a valid comparison.
Articles were excluded if they did not involve data linkage, such as a discussion of another form of health information technology; if they did not involve data, such as a commentary, letter or discussed a data linkage methodology without an empirical evaluation or if they presented a linkage project without comparing characteristics in matched and unmatched records.
Therefore, the results of such studies can be "incongruent with their stated methodological choices and the research product is a mixture of different methodologies without convincing justification".
However, the proposed approaches have presented specific methodologies without using development standards, which may be followed by developers.
However, the existing work mostly focuses on the solution domain of a pattern while leaving out the problem domain, structural pattern aspects with little attention to behavioral aspects, and general methodologies without concrete implementations.
Furthermore, most of the aforementioned studies have only focused on developing ad-hoc parameters and rules and were mainly developed according to theoretical backgrounds such as mathematics, physics or bionics-inspired methodologies without much study of human physical, psychological and cognitive behaviors.
Moreover, almost all of the few aforementioned studies and existing models only concentrate on developing ad-hoc parameters or rules and are mainly developed according to theoretical backgrounds such as mathematics-, physics- or bionics-inspired methodologies without much consideration of human physical, psychological and cognitive behavior.
The wide variation in the relationship between dose and levels has also indicated the difficulties in spot sampling methodology without a population pharmacokinetic model [37], as well as the potential impact from the subject's inhalation technique, particularly when an MDI device is used [38 40].
Therefore the emergence of facile, convenient, and environmentally benign methodologies without tedious operations is desirable.
