First, using established methodologies we showed that photoexcitation of IAs results in the formation of singlet oxygen and superoxide anion.
Using a combination of in-vivo optical imaging and immunolocalisation methodologies, we showed that systemically administered Cy5.5Angiopep-2 ANG10051005 passed through the BBB in mice and subsequently accumulated at higher levels in orthotopic human glioma tumours than in contralateral non-tumour brain tissue.
By this methodology, we show that the moments provide a concise summary of the distribution, showing statistically-significant differences across much of the feasible parameter range.
Moreover, using our methodology, we show that indel parameters substantially vary between three genomic data sets: Mammals, bacteria, and retroviruses.
In terms of methodology, we show that high-quality de novo assembly of transcriptomes can be achieved using Illumina sequencing technology with the Trinity assembly pipeline.
By combining the reporter system with virus-based tracing methodology, we show that the new neurons integrate into local circuitry in an efficient manner.
To demonstrate the feasibility of our methodology, we showed that is it possible to obtain accurate and reliable P- and S-wave ultrasonic velocities measurements and the Thomsen parameters (ε and γ) related to them, even if the sample presents a high fracture density, due to the high quality of the acquired waveform, expressed in a high signal-to-noise ratio.
While developing the promoter knock-in methodology, we showed the importance of conserving the natural leader region containing the ribosome binding site (RBS) of the gene of interest and of eliminating upstream regulatory elements (transcription factor binding sites).
A real case illustrates the methodology used, and we show that in such deep marine environments possible lateral geological variations are deduced from transient pressure analysis, such as sand pinching out or lensing, which could not be inferred from other static measurements.
Simulation results show the benefits of the control methodology used: in particular we show how very effective distribution of braking torque are obtained as a result of this feedback policy.
