We used this methodology to look at folding-energy related differences at those sites under different functional constraints when comparing GroEL copies (for example, highly constrained amino acid sites in one GroEL copy but showing lack of constraints at another GroEL protein copy) and estimated the significance of these differences.
The QFT design methodology alows to look for real solutions to the problem.
These methodologies allow us to look at a more diverse spectrum of wind events including non-stationary, non-synoptic winds and their impact on buildings and structures.
Our methodology has been to look for those TFs that potentially affect genes producing proteins that influence extracellular matrix, or to those TFs that are both co-regulated and co-expressed with such genes.
Our methodology was developed to look for all orthologous microsatellites for which PCR primers could be potentially designed in supposedly unique genomic sequences for downstream cross-species applications, for example, comparative mapping, population genetics of nonmodel species, and study of interspecies microsatellite evolution.
In the search for new statistical methodologies, it is helpful to look to other fields that deal with similar problems in modeling data with many variables and complex interactions.
By contrast, our air sampling methodology was not designed to look at day-to-day fluctuations but rather at chronic exposure levels during the final 2 months of pregnancy.
Summary: This work begins a new effort to combine modern genomics methodologies with new computational approaches to look at how organisms exist within the environment.
As Yin (2009) maintains that case studies allow not only for the examination of particular complexities in a case but also enable researchers to gain insights into larger systematic issues an appropriate methodology for researchers who want to look at an issue using both close- and long-focus lenses.
Unlike previous studies that have looked only at the contributions of individual transcriptional regulators, we used a powerful and sensitive methodology, RNA-seq [ 16], to look at the environmental condition of anaerobiosis as a whole.
