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We employed similar methodologies to elucidate the molecular mechanisms of integrin and extracellular matrix interaction in regulating leukocyte function.
A genetic approach to identify RA-associated genes from the whole genome is proposed to be one of the promising methodologies to elucidate the etiology of RA.
This PAR solicits applications from investigators in these different fields to combine these data, reagents and methodologies to elucidate the genetic basis of cell biological events, including embryonic development and organogenesis.
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Site-specific labeling is an important methodology to elucidate the biological function of a target protein.
We conducted a workshop attended by diverse participants involved in conservation of large carnivores in the northern U.S. Rocky Mountains, and used Q methodology to elucidate participant perspectives regarding "problems" and "solutions".
In addition to the classical testing methodologies, the detailed analytical investigation represents a powerful methodology to elucidate the molecular composition and modification of plastic bio-polymers thereby providing a valuable contribution to further promote the composting process as viable way to recycle the biodegradable polymeric materials.
We have developed quantitative HPLC methodology which resolves CoA, acetyl-CoA, acetoacetyl-CoA, and β-hydroxybutyryl-CoA with baseline resolution and then utilized this methodology to elucidate the fluctuations in metabolite concentrations and the effect of each individual enzyme on the overall system.
Since ob/ ob mice are hyperphagic, chronic administration of dapagliflozin in food could provide improved exposure/effectiveness. Detailed, multiple dose-interaction studies may be required (e.g. response surface methodology) to elucidate optimal long-term dose combinations that may reveal potential additivity or synergy.
Improvements in instrumentation and statistical methodologies continue to elucidate ECoG correlates of normal human function as well as the ictal state.
(4) Whereas MLE tends to focus on estimating best fit parameters, the Bayesian methodology attempts to elucidate posterior parameter probability distributions.
These findings identify an inherent inability of the signature tag methodologies to accurately elucidate fitness in this animal model of infection and underscore the subtleties of H. influenzae gene regulation.
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