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Together the inconsistencies of the findings highlight the need for employing more powerful immunoassay methodologies to clarify the frequency of autoantibodies in ASD.
Future studies should use robust mixed-methods research methodologies to clarify causal mechanisms underpinning quality improvement interventions, and to identify those most likely to promote more reliable delivery of best practice throughout the healthcare system, as well as promoting clinician ownership.
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We contacted the investigators in several of the studies to confirm trial methodology and to clarify specific outcome data.
Fortunately, the application of newer methodologies has begun to clarify the dynamics and molecular bases of renal uric acid excretion.
Whilst studying the cough challenge methodologies we wished to clarify whether, as it does in animals [ 22], citric acid administration causes significant bronchoconstriction, we used impulse oscillometry to measure any change as this has been claimed to be a more sensitive test than spirometry [ 23].
In this paper, we first present the methodology in order to clarify the basic thread of this model.
Additional studies in larger homogeneous populations with validated methodology are needed to clarify these issues.
Bhaskaran et al pointed out that further research with consistent methodology is required to clarify the magnitude of these effects and to identify susceptible groups [ 5].
Research into factors that influence Aβ in the periphery and increased attention to assay methodology have helped to clarify the potential and limitations of plasma Aβ levels as indices of AD risk [ 4].
To explore the mechanisms behind the link between snus use and SES is, however, not within the scoop of this study, and would also need other methodologies, preferably qualitative methods, to clarify.
Authors were contacted in an attempt to clarify methodology and to request additional data when a study was excluded because the data could not be used [ 15- 21].
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