Using the conventional hESC derivation methodology starting from blastocyst ICM cells, the embryo would be destroyed.
The methodology starts from a proper design of passive dynamic vibration absorbers, which are transformed into active absorbers by the addition of extra actuated degrees of freedom, leading to nonlinear dynamical systems.
The methodology starts from a suitable assembly system selection and thereafter decides suitable cycle times, parallel workstation requirements, and parallel line implementation for the type of assembly system being selected.
The proposed methodology starts from a requirements model, which defines a business domain at a "strategic" level, describing the participating actors, their mutual dependencies, goals, require- ments, and expectations.
The methodology starts from the physics of SILC dynamics and oxide damage, and relies on the trade-off between duration and amplitude of short voltage programming pulses, minimizing the creation of new traps in the tunnel oxide.
Concerning the hand-opening impairment, the authors have also developed a methodology which, starting from the geometrical characteristics of the patient's hand, properly defines the novel kinematic mechanism that better fits the finger trajectories.
Refinement techniques of (system) models improve the process by using a proof assistant, and by applying a design methodology aimed at starting from the most abstract model and leading, in an incremental way, to the most concrete model, for producing a distributed solution.
In order to explore on a wide basis the links between hypoxia and placental diseases, and to identify early putative markers of the preeclamptic pathology, we combined the Subtractive/Suppressive Hybridization (SSH) methodology starting with cDNA material obtained from first trimester placental purified villi with the construction of high-density nylon macroarrays.
The methodology is introduced comprehensively starting from the conceptual framework design to mathematical modeling and to decision making based on cost benefit analysis.
We explain the methodology for DR/DSM implementation, starting from DR/DSM capacity and feasibility investigation to program modeling and its introduction and expansion.
