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Our ability to test the performance of these methodologies is limited, however, by the availability of a catalog of synergistic drug combinations.
Recently it has been shown that the correlation between measurements of ocular hemodynamics with different methodologies is limited.[ 30] Thus differences in outcome between studies investigating the effects of the same compound on ocular perfusion might at least partially be explained by the variability between the methodologies.
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However, these methodologies are limited due to the difficulty in achieving accurate results, the complexities in their theoretical model and the amount of sample required for measurements.
Although the idea of HKES and similar hybrid systems have already been applied in various fields, such as product design, engineering design, and system optimization, most of existing methodologies are limited by searching optimal design solutions using single-objective optimization (SOO), instead of multi-objective optimization (MOO).
However, current methodologies are limited in terms of the capacity to isolate and expand a sufficient quantity of endogenous antigen-specific Tregs for therapeutic intervention.
While promising, many of these methodologies are limited by their use of expensive and complex work flows and/or result in poor reproducibility of labeling between different antibodies.
Better understanding of the microorganisms explains, in part, why our current typhoid methodologies are limited in their diagnostic information and why developing new strategies may be a considerable challenge.
Scientific methodology is limited to finding explanations for natural phenomena in naturalistic terms.
Like most graphical techniques, the presented methodology is limited to single contaminants.
Unfortunately, the availability of the RT-PCR methodology is limited in low-resource settings where this disease is commonly found.
The preprocessing of proposed methodology is limited to extract foreign words, emoticons and elongated words with their appropriate sentiments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com