In the game development process, quality assurance and process validation are critical components, and standard methodologies are lacking.
While technology facilitates the measurement of hundreds or thousands of genes, statistical and computational methodologies are lacking for the analysis of these data.
The spectacular effects observed during acoustic cavitation phenomena have been successfully employed for a number of applications on laboratory scale of operation but a well defined design and scale up methodology is lacking.
KRAS gene mutations can be detected by several methods (van Krieken et al, 2008); each has limitations and a gold standard methodology is lacking (Bellon et al, 2011).
We will also identify gaps where methodology is lacking, and we will be able to highlight the potential for novel statistical advances necessary to evaluate the key assumptions in NMA.
In contrast to phospho-EGFR, EGFR expression in primary colon cancers has been shown to be an adverse prognostic marker in some (Lee et al, 2002; Resnick et al, 2004), but not other (McKay et al, 2002; Spano et al, 2005), studies and an evaluation of its prognostic effect using the FDA-approved antibody and methodology is lacking.
Identifying biologically relevant differences between IPF patients that remain stable or show slow progression compared to those who rapidly progress is an active area of investigation but to date a detailed understanding of the gene expression pattern in IPF patients segregated into stable or rapidly progressive groups using standard methodology is lacking.
Classification criteria for CV developed by a standardised methodology were lacking, though they are crucial in clinical practice, scientific communication and epidemiological surveys.
A systematic evaluation of the methodologies of sustainability ratings is lacking.
Nursing research is not well-developed in Italy, and knowledge of the methodologies for conducting research is lacking.
