Now this kind of methodologies is challenged by the nature of big data in four Vs volume, value, variety, and velocity (Zhao et al. 2014; Fan et al. 2015).
To this regard, finding a suitable testing methodology is challenging due to the lack of upfront clue on the actual usage pattern of the environment.
Although necessary, this type of multidisciplinary methodology is challenging in complexity and scope.
While the technique holds great promise for analysis of biological samples, current methodologies are challenged by a lack of automatic analysis software e. g. for selection of regions of interest and statistical comparisons of sample variability.
The Abstinence, Be Faithful and use a Condom prevention methodology is challenged by supply chain problems, anti-condom sentiments by some religious groups, and limited incorporation of cultural concepts of sex in HIV prevention [ 3, 15].
Although Mill's views on economic methodology were challenged later in the nineteenth century by economists who believed that the theory was too remote from the contingencies of policy and history (Roscher 1874, Schmoller 1888, 1898), Mill's methodological views dominated the mainstream of economic theory for well over a century (for example, Cairnes 1875).
Although theoretically feasible, application of this methodology to mice imaging is challenging, owing to the very small size of the mouse heart.
However, fabricating such a methodology at a large scale is challenging.
Multiple reports of studies evaluating the percentage of HER2 positivity in individual cancer types have shed some light on the distribution of HER2 positivity across individual cancer types [ 13]; however, given a lack of standardized methodology and interpretation criteria, it is challenging to compare the rate of HER2 positivity across studies and tumor types.
A general outline of the solid-phase synthesis (SPS) method is illustrated in Scheme 2. In terms of developing this methodology, the amide bond forming reaction is challenging as the substrate is a deactivated aniline.
