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These previous methodologies have several limitations such as poor reaction efficiency and low yields, limited choices of protein reagents (e.g., specific DNA modifying proteins), and insufficient site specificity in respect to the cross-linking site within the protein.
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We note that our analysis and methodology have several limitations.
Despite limitations, this study and its methodology have several strengths.
The proposed methodology has several advan tages such as computational efficiency and automatic functional modelling in reverse engineering.
Even if each methodology has several advantages and disadvantages, this work focuses on the end-to-end approach because it does not involve any congestion explicit signaling from the network elements; therefore, it is highly deployable, with easy installation and utilization, and it requires modifications only in the terminal devices, without direct involvement of intermediate nodes.
The methodology has several potential applications, including its use to derive a pre-coordinated guide for ST assignments to new UMLS chemical concepts, as a tool for auditing existing concepts, inter-terminology mapping, and to serve as an upper-level network for ChEBI.
The systematic review methodology has several key principles: transparency, comprehensiveness and evaluation of the primary research study design.
Our methodology has several strengths.
Our study methodology has several strengths.
The CLEA methodology has several additional advantages compared to alternative methods for immobilization of enzymes.
However, this purely correlational methodology has several important shortcomings that have been frequently criticized (e.g. [ 13, 19, 51, 52]).
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