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Several methodologies have previously been employed to increase sensitivity.
In PCDD/F epidemiology, GIS-based methodologies have previously been applied to detect cancer clusters around a municipal waste incinerator with high PCDD/F emissions (Viel et al. 2000) and to model airborne exposures to PCDD/Fs (Cohen et al. 2002; Floret et al. 2003; Stellman et al. 2003).
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Details of the MRI methodology have previously been described (Jack et al., 2008).
The details of the cohort and IHC scoring methodology have previously been described in detail [ 19, 20] and in Additional file 1A.
The WHO EPI survey methodology has previously been criticised for lacking methodological rigour and for introducing bias.
A methodology has previously been proposed that employs a shotgun-like grid-based approach to systematically cover entire brain volumes with injections of neuronal tracers.
This same scenario-based methodology has previously been used to study the effects of congestion on accessibility.
Among the countries where the methodology had previously been employed were India [30] and Pakistan [31], which have many similar problems.
Our experimental methodology has previously allowed us to locate discrete somatotopic maps of the digits in areas 3b and 1 [9].
A similar methodology has previously been used [ 1, 2].
The methodology has previously been outlined in detail [ 17- 19].
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