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A recent elegant study using optogenetic methodologies has provided more direct evidence for presynaptic functions of DISC1 in the neocortex of Wistar rats (Maher & LoTurco, 2012).
The use of molecular biological methodologies has provided a greater understanding of the cytotoxic effects of cisplatin and the underlying mechanisms of tumour cell resistance.
Within the past 6 years, the advent of high-throughput sequencing methodologies has provided researchers and clinicians with an extremely powerful tool for querying large amounts of the genetic landscape within not only single individuals but also cohorts of many individuals.
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In the past three decades computing methodologies have provided the designer with unprecedented tools to explore highly complex forms, create digital models and fabricate them.
While this behavior has been studied in depth for simple linear block copolymer amphiphiles, recent advances in synthetic methodologies have provided efficient routes to amphiphilic polymers with more complex architecture, including dendrimers, hyperbranched polymers, star polymers, and cyclic polymers.
Neuroimaging methodologies have provided much information on the shift in neural activity patterns in sleep, but the dynamic restructuring of human brain networks in the transitional period from wake to sleep remains poorly understood.
More recently, the development of individual identification, satellite telemetry and particularly genetic methodologies have provided powerful additional means of investigating cetacean population structure and even testing the validity of some potential biological and ecological boundaries of the management units used by the IWC [33].
New methodologies have provided global identification of in vivo mRNA targets of different RBPs.
MS-based methodologies have provided significant advances in accurate and sensitive quantitation and the ability to multiplex vastly complex samples through the application of robust bioinformatic tools.
Other national studies in Europe, using heterogeneous sources and methodologies, have provided HPV prevalence data in women aged <30 years prior to widespread HPV vaccination.
The adaptation of this methodology has provided more robust assessments that can be used by community members and service providers.
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