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The employment of recent advances in high throughput profiling methodologies has allowed the system-level characterization of C. reinhardtii at transcriptomic [ 11, 15, 33], proteomic, and metabolomic levels [ 19, 21, 34].
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The ability to manipulate genes through cloning and expression methodologies have allowed for the development of novel chimeric receptors to selectively target cancer when introduced into immune cells.
Important advances in data quality and methodologies have allowed for better investigation of disease risk and its association with environmental factors.
The use of the biosensor in a combination with other methodologies have allowed us to determine that the levels of cell surface-associated furin are exceedingly low and that they represent a diminutive fraction of the total cell furin.
These screening methodologies have allowed the further identification of GPCRs, which respond to fatty acids with individual GPCRs showing relative selectivity to fatty acid chain length and degree of saturation (14).
A modular and hierarchical modeling methodology has allowed a graphical modeling development.
This methodology has allowed for a rigorous statistical evaluation of potential departures from additive interactions in endocrine active mixtures.
Rasch methodology has allowed performing a short questionnaire composed of 17 items able to measure HEN-related HRQoL irrespective of the patients' underlying disease and the route of administration.
The third step, finally, always through the same query inferential methodology has allowed to switch from the maps of geographical regions characterized by homogeneity of features to the maps of the risks and environmental pressures (Fig. 7).
The application of 10 years experience of controller implementation and commissioning combined with a modern and efficient modelling and design methodology has allowed an unprecedented fast and easy commissioning of the new system.
Although the synthesis of many such compounds was once considered nearly impossible, aldol methodology has allowed their efficient synthesis in many cases.
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