Although policy-makers were willing to engage in hypothetical discussions about the methodology, difficulties in identifying potential pilots suggest a wider problem in encouraging take up without legislative imperatives.
12 Maddox demonstrated only mixed support for a two-factor methodology due to difficulty in categorizing ambiguous outcomes.
A major challenge in optimizing metabolomic methodologies has been the difficulty in comparing the number of metabolites profiled in each.
There was also difficulty in the methodologies with two-dimensional radiographs when performing superimposition of tracings [25]; however, in the present study, no superimpositions were made.
There is considerable uncertainty about the range and substance of these methodologies, and there remains a difficulty in trying to articulate their aims and content.
One of the problems in the application of engineering methodology to hygiene is the difficulty in expressing dirt and cleanliness in objective, exact and quantitative terms.
However, there have been several major criticisms of the method: (a) the high chance of overfitting the data, (b) the lack of easy interpretation of the model and of the impact of individual covariates, (c) the perceived 'black box' methodology involved, and (d) the difficulty in handling censored survival times.
The application of the snowball method, one of the most traditional non-random methodologies, presents some difficulties in determining the initial list and thus risks introducing significant biases, and the probability of inclusion in the sample is unknown.
However, these methodologies are limited due to the difficulty in achieving accurate results, the complexities in their theoretical model and the amount of sample required for measurements.
The molecular mechanisms underlying this increase in permeability are still not clear, not least due to the difficulty in reconciling different methodologies of permeability measurement, with the respective changes in molecular interactions.
