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Since different methodologies confirmed the interaction of RB1 with components involved in cNHEJ, we assessed whether RB1 affects NHEJ activity in cells.
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In that publication the authors write that the methodology "confirmed the partition of worldwide diversity into five genetic clusters that correspond to major geographical regions" (p. 658), that is, Africa, Europe, America, Oceania, Middle East, East Asia and Central/ South Asia.
The proposed methodology confirms the applicability of reaction engineering principles for scale-up, from bench to pilot-plant photoreactors.
However, the present larger study based on an optimised methodology confirms the clinical utility of this TP53-based diagnostic to provide a test with a high sensitivity for mutation detection.
The optimisation methodology confirmed this indirectly by evolving a panel displaying a delayed secondary instability whilst meeting all other design requirements.
Thus, in an independent, external heterogeneous HNSCC cohort assessed by an orthogonal quantitative methodology, we confirmed the infrequent methylation events for the loci examined.
X-ray diffraction analysis, scanning electron microscopy coupled with energy dispersive X-ray and the experimental design using response surface methodology confirmed that the main mineral patterns in P-rich granules were Ca Mg phosphate and whitlockite.
For both SBR and CFBR, the application of different methodologies confirms that mass transfer phenomena are not controlling the bioreaction.
The results show that the adopted methodologies of studies confirmed the capabilities of the codes to simulate specific situations in steady state or transient operating conditions.
These simulations have confirmed the methodology to be adopted for design of wind tunnel subsections.
The results of this application confirmed the methodology's capacity to determine the soil color from NOAA/AVHRR data.
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