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Reliability-based design is one of the design methodologies, but is highlighted as a separate section in this chapter.
Typically, the Loss of Load Probability (LLP) is a key parameter in these methodologies, but is difficult to set as regards the specific context.
This can easily be accomplished with light microscopy or flow cytometry-based methodologies, but is exceedingly laborious by transmission electron microscopy.
Thus, CheMA can complement existing methodologies but is not at present applicable to truly high-dimensional problems with hundreds or thousands of nodes.
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Some studies used otherwise appropriate methodologies, but were rated as "poor" due to inadequate sample sizes for analyses.
This is not based on a given methodology but is our interpretation.
This extension of the animal model is in principle possible using the INLA methodology, but is limited by the number of hyperparameters and is not yet implemented in the software.
We believe that almost complete reactivation of Atrx would be required to allow the detection of a Atrx signal at the site of transcription on the Xi with our FISH methodology, but is likely not attained upon our treatments [ 38].
Furthermore, our approach did not follow any strict methodology but was quite loose.
(The mentors in our program are there to support the methodology, but aren't there to tell stories).
This "by-product" feature is not necessarily inherent to the LAD methodology, but was identified during our LAD experiments.
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