Question 1: The individual steps and the overall methodology are rather standard.
However, investigations have shown that the influence of economic evaluation on decision-making and the knowledge about the formal methodology are rather limited [ 7, 9, 39].
Nonetheless, this analysis methodology was rather qualitative and laborious, and the outputs it provided were greatly subjective.
Albeit rigorously formulated, the methodology was rather limited in performing aggressive optimizations because of the halo inherently inserted by the heuristic flexibility functions.
The limitations of this research are that the methodology is rather time consuming in order to be detailed and robust, and that the public were not included as participants.
As the overall methodology is rather complex, particularly the collection of the hybridized array-enriched DNA sequences, the difference between samples is most probably influenced by technical factors such as variations in hybridization, washing conditions and potential reuse of the capture array.
Experimental tests showed that the devised methodology produces results that are rather close to those obtained by human subjects and, for some of the metrics considered, can provide improved performances with respect to alternative techniques.
While the methodology itself is rather involved, being based on the theory of Gaussian Markov random fields, the actual computations are reasonably fast.
The methodology applied here was rather robust given the additional analyses performed.
In general rather complicated methodologies are needed for the combination and comparison of information as obtained from selected analytical platforms.
