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Extensive efforts to characterize the reproducibility of microarray methodologies and platforms have been carried out previously [21], [22], showing that careful attention to methods can yield predictable reproducibility.
The prevalence of high resolution profiling of genomes has created a need for the integrative analysis of information generated from multiple methodologies and platforms.
The main advantage of these methods is a greater ease of interpretation and increased comparability among different experiments, methodologies and platforms.
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After all, using (initially) the same criteria, methodology and platform, the neuroepithelial transcriptomes of the ocular NPE and PE differed only by 1% [ 16] and the transcriptomes of the macular and peripheral RPE only by 1-51-5%15].
The variety of methodologies and sequencing platforms in the marketplace for TGP has resulted in a variety of clinical TGP laboratory developed tests (LDT).
In addition, there are differences in both RNA isolation methodology and microarray platforms.
Recently, we have developed an automatic methodology and prototype platform to facilitate scientific verification of individual functions within complex scientific codes.
Founded in 2008 by technology entrepreneur James Booth and TV executive Torie Chilcott, Rockabox, described as a new breed of cross-media IP-creation and exploitation business, creates and delivers "engaging cross-media entertainment formats" that are supported by the company's marketing methodology and technology platform.
Yang et al. [ 12, 13] previously used the same methodology and sequencing platform to identify markers linked to anthracnose and stem blight in lupin.
In addition to a mounting volume of data to manage, the different origins, reagents, methodologies, experimental platforms and data formats pose a major challenge to maintaining consistency and clarity in the processing and presentation of the collected data.
The SNPs may have resulted from the use of different platforms, methodologies and software, however, it cannot be ruled out that genetic changes have occurred during the period of separation.
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