To address this issue, the International Ki67 in Breast Cancer Working Group has recently released guidelines, based on current evidence, that should allow harmonisation of methodology and lead to the definition of the clinical utility of this potentially important marker (Dowsett et al, 2011).
Ho also questioned Richman's methodology and led him into a trap.
JT conceptualised the study and its methodology and led the data analysis and interpretation stage.
MKK co-designed the classification schemes and the methodology, and led the work.
IB designed the methodology, and led the sample preparation, mass spectrometry, and data analysis, as well as contributing substantially to the manuscript.
With most permanent researchers in the survey having a tenured position and most researchers on temporary contracts being postdocs, many factors, such as experience and age, could explain these differences in productivity, Siobhan Phillips, a senior science officer at ESF who was the survey methodology adviser and lead author, says in an email to Science Careers.
She is also interested in qualitative and mixed method systematic review methodology, and is Lead Convenor of the Cochrane Qualitative and Implementation Methods Group.
She has a specific interest in systematic review methodology, and is Lead convenor of the Cochrane Qualitative Research Methods Group and Co-Chair of the Cochrane Methods Board Executive.
Contemporary drug development is an ordered process starting with identification and validation of a target with high throughput methodologies and going through lead identification and optimization to preclinical and clinical trials of drug candidates [4].
To date, in spite of the increasing number of reported AMPs from plants, developments in gene expression methodologies and computational algorithms lead to new prospective strategies of biomining AMPs in plant systems.
