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Despite recent progress in genome assembly methodologies, a significant portion of many genomes remains inaccessible to assembly by short sequencing reads [ 10].
First, owing to intrinsic limitations in the experimental methodologies, a significant fraction of the observed protein protein interactions are likely to represent false positives, i.e. interactions that do not occur in vivo under physiological (or pathological) conditions.
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Using this methodology, a significant number of new families of distributions have been defined and studied.
For the hot injection methodology, a significant discrepancy with respect to obtained sizes and applied reaction conditions is reported.
Combined with trans-membrane transport dynamic and response surface methodology, a significant influence of temperature, pH and salinity on cellular uptake rate was screened by Plackett Burman design.
In a pilot study on gilthead seabream using the same methodology, a significant change in cortisol levels of a control group not subjected to stress was observed, but there was no significant additional effect of ice-water on a group subjected to confinement stress (A. Canario, unpublished observations).
The complexity of hardware design methodologies represents a significant difficulty for non-hardware focused scientists working on accelerating the simulation of complex bio-inspired applications.
While these methodologies represent a significant advance in resequencing throughput, they do not provide the ability to target sequencing to specific disease-linked loci.
Increased attention to cancer cluster methodologies represents a significant advancement in its own right; however, published recommendations for method selection vary, and the need for extensive systematic comparisons of different approaches remains (Jacquez 2004; Wartenberg 1995; Wartenberg and Greenberg 1993).
This was validated using data from the huperzine A clinical trial, where the ADAS-CogIRT methodology detected a significant improvement in the praxis domain that had been overlooked using the current scoring methodology.
This methodology represents a significant improvement over penetrometer methods that only use single-value surface breaking point information.
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