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The methodologically strong studies in this area were Strakowski et al. (2010) and Martino et al. (2011).
Three further systematic reviews were inconclusive and determined that further methodologically strong studies were needed that include the assessment of potentially confounding factors such as expectation and belief.
A further limitation of this review is that it synthesizes only methodologically moderate articles, as no methodologically strong studies were found and weak studies were not discussed in detail.
We have surmounted these limitations and in addition provide in-depth analyses of methodologically strong studies, the effects of adjusting for socioeconomic status, and comparisons of risk associations against different types of vascular events and different shift work schedules.
The question as to whether more targeted and multiple session interventions in high-risk persons make more sense not only with adults [ 14] but also with children can be answered only by methodologically strong studies with children and adolescents.
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With regards to the ability to delay gratification, the two methodologically stronger studies found little evidence of group differences.
Only five studies explored delay of gratification, of which the two methodologically strongest studies found no group differences.
This is illustrated when two of the methodologically strongest studies, the American Paediatric Heart Network study 10 and the recently reported Japanese RAISE study 14 are considered in more detail.
The most convincing and methodologically strongest studies to date have been population studies utilising individual level data by examining the effect of deaths occurring in the antenatal period in both the nuclear and the extended family.
One of the methodologically strongest studies conducted so far was by Biegel, Brown, Shapiro, and Schubert (2009), who evaluated the MBSR-T intervention with young people receiving community mental health support.
Ernst et al. [ 12] stated that the weaker studies implied benefits of VA-E, partinularly in terms of quality of life, while none of the methodologically stronger studies were able to verify a benefit with respect to survival or quality of life.
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