For the other two studies, greater than 80% of the participants received their assigned allocation and were thus deemed methodologically strong on this component.
However, the methodologically strongest single study, a prospective study in children, found only 4 of 9 estimates elevated, with ORs ranging from 0.6 to 1.8.
Methodologically strong research is needed on which to base decisions on investment in stigma-reducing interventions.
This analysis draws on data collected from a methodologically strong trial, uses an appropriate method for assessing cost-effectiveness, captures the role of uncertainty among model parameters, and presents the results in a format suitable for interpretation by decision makers.
In view of the magnitude of challenges that result from mental health stigma and discrimination, a concerted effort is needed to fund methodologically strong research that will provide robust evidence to support decisions on investment in interventions to reduce stigma.
Given the magnitude of the challenges posed by stigma and discrimination, it is clear that there needs to be a commensurate concerted effort to fund methodologically strong research to provide robust evidence to support policy decisions on investment and interventions.
In contrast, all but one of the trials included in the depression meta-analysis were methodologically strong.
Of the relevant studies, 0 were rated methodologically strong, 10 were moderate, and 74 were weak (see Figure 1).
"The strong ones eat everything.
Yet, these other studies are not as methodologically strong as the national randomized trial and their results are sometimes implausibly large and mysterious compared to those in the rest of the research literature much of which is less favorable.
