However, when only methodologically robust trials were included in the analysis a smaller effect in favour of exercise was observed.
Statistical analysis of the matrix data may be restricted because of the limited data points that mixed review evidence could provide but further analysis could explore, in a review with more methodologically robust trials, the value of using the algorithmic logic of QCA to explore variation in trial findings.
Further research, in the form of methodologically robust randomized trials, are needed to evaluate this strategy in different maternity care systems and countries.
Notwithstanding the difficulties underlying the execution of this type of complex clinical trials, larger and methodologically more robust trials are very much needed to confirm the findings of the present review, and to further identify characteristics of successful programs.
Finally, based on these discussions, description of a methodologically robust, definitive clinical trial will be proposed.
Therefore, we based our feasibility assessment upon methodologically robust exercise oncology trials.
Nutritional and dietary supplementation in haemodialysis patients is an area which requires larger, more methodologically robust randomised controlled trials to determine if risk of cardiovascular outcomes can be improved.
New studies are needed and these should be methodologically robust and follow the clinical trial guidelines from IHS in order to provide data for the rationale of CAM management in headache.
First, the evidence from any given clinical trial, however methodologically robust, may or may not pertain to any given patient.
A methodologically robust method is to test for a subgroup-treatment interaction effect.
