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In the absence of methodologically rigorous evidence, the delivery of Indigenous drug and alcohol residential rehabilitation services vary widely, and divergent views exist regarding the appropriateness and efficacy of different potential treatment components.
Yet we meant to do it this way because randomized controlled trials are considered to provide the most methodologically rigorous evidence.
In an attempt to clarify the comparative effect of prolonged versus intermittent infusion β-lactam antibiotics on mortality, clinical cure, and adverse effects, we analyzed RCTs that offered the most methodologically rigorous evidence from the available studies.
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There is evidence from methodologically rigorous controlled trials that exercise, psycho-educational interventions, and cognitive-behavioral therapy for insomnia are effective in the treatment of CRF, and a wide range of pharmacologic and nonpharmacologic interventions has shown initial promise in single-arm pilot studies with small, heterogeneous samples.
This has allowed for a methodologically rigorous investigation resulting in empirical evidence to support our hypothesis.
The recommendations of the Guise systematic review highlighted the need for further research that 'should focus on conducting methodologically rigorous studies to provide direct evidence regarding the relative benefits and harms of VBAC and ERC.
In this study scientific evidence refers to methodologically rigorous research, such as randomized controlled trials (RCTs).
There is a need to develop a robust methodology to perform methodologically rigorous and transparent cost of illness studies to inform policy decisions.
GRADE suggests considering rating up the quality of evidence in case of methodologically rigorous observational studies (10).
GRADE suggests considering rating up the certainty of evidence by one level when methodologically rigorous observational studies show at least a twofold reduction or increase in risk, and by two levels for at least a fivefold reduction or increase in risk.
This novel and timely research will implement a methodologically rigorous RCT of two interventions which already have substantial evidence of efficacy in treatment of late-life depression in healthy people.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com