Nevertheless, methodologically more rigorous assessments (e.g., clinical interview) should be conducted to determine if these patients meet the criteria for clinically significant depression.
The UNITE study is a novel and methodologically rigorous means of assessing clinicopathological correlation in CTE.
There is still a dearth of methodologically rigorous studies to assess interventions to combat or prevent drug counterfeiting.
There is a need to develop a robust methodology to perform methodologically rigorous and transparent cost of illness studies to inform policy decisions.
Since results of some of these analytical and intervention studies do suggest improvement in knowledge, skills and behavior through courses based on the critical appraisal approach, [ 3, 7, 14, 19, 40, 41] assessment by more methodologically rigorous study designs would be more effective in demonstrating the perceived increases in CMR-JC.
Rasch analysis has increasingly become popular in assessing the quality of existing outcome assessment tools and in developing new ones [ 17, 18], as it offers a methodologically rigorous way to evaluate and enhance the measurement properties of the assessment tools [ 19, 20].
Few studies, however, use methodologically rigorous designs and include both program participants and nonparticipants in assessing outcomes linked to participation.
The impact of the use of a fall risk assessment tool on clinically relevant endpoints has never been investigated within a methodologically rigorous trial.
The RCT by Schwarz et al. [19] appeared to be the most methodologically rigorous but was still rated unclear since only the study protocol and abstract were available for assessment.
The inclusion of less methodologically rigorous evaluations increased the volume of material identified and reviewed and also presented methodological challenges with regard to quality assessment.
