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We conclude that blinding is optimal, but methodologically difficult.
Unfortunately, prospective surveillance of ED-placed invasive lines is methodologically difficult.
Their evaluation, however, is methodologically difficult and the few existing studies are controversial.
In the case of the moving inertial load the classical time-integration schemes are methodologically difficult, since we consider the Dirac delta term with a moving argument.
Two studies from English-speaking samples investigated the methodologically difficult question of whether the later reading achievement of children learning to read earlier or later differs.
In addition, HCWs commonly over estimate their knowledge and practices on infection prevention [13], [16], [35], the magnitude of which is methodologically difficult to estimate.
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Investigations on the relationship between sepsis, brain dysfunction, and cerebral perfusion are methodologically very difficult to perform.
To address these types of questions and adequately incorporate the needs, preferences and experiences of patients into healthcare delivery, there is an increasing need to consider less traditional review methods of complex evidence (i.e., heterogeneous, methodologically diverse, difficult to classify, and contradictory) [ 12, 13].
In gastric cancer, methodologically, it is difficult to isolate and amplify CSCs from cell lines or tumor tissue specimens.
Despite methodologically and conceptually difficult factors involved in this strategy, it has not discouraged us to explore similar avenues for molecular predictor discovery in MM and multivariate bioinformatics tools.
Methodologically, it was often difficult to pin down 'who' was being assessed.
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