Moreover, although it is not methodologically correct to compare different studies, these data seem to suggest that the combination treatment with bevacizumab and fotemustine may be more active and tolerable than lomustine in patients with high grade gliomas.
The studies were methodologically correct and well accomplished and provided new results, with the exception of the improper use of ICRP 103 weighting factors (see Discussion).
To the authors´ knowledge, whether methodologically correct or not, there are no study validating either of them.
As suggested by Dr Scolletta, Bland Altman analysis has been re-examined and performed as "Bland Altman analysis for repeated measures", which is the methodologically correct test to perform in such a study.
All criteria for a methodologically correct stage 2 (definition of outcomes and predictor variables, generalisability of subject selection, several statistical and methodological demands) are present in this study, except the inter-observer reliability for the clinical findings, which is difficult to measure in the acute setting in primary care.
In any case, the validity of the conclusions of tissue engineering will have to be verified in human clinical models using methodologically correct prospective epidemiological designs.
Often using small or methodologically flawed studies as evidence, positive psychologists restate over and over the claim that money is of minimal importance to wellbeing.
Forest Ecosystems will encourage methodologically diverse studies, employing both quantitative and qualitative approaches.
Reporting bias was minimised by including all available methodologically sound studies (published or not).
Unfortunately, few methodologically rigorous studies exist to guide clinical practice.
