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The small number of methodologically adequate evaluations of programs means there is limited high-quality evidence that service providers and policy makers can use to improve the effectiveness of programs for high-risk young people.
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Consequently, there is a concern whether psychiatric clinical trials are methodologically adequate and, if not, which aspects of trial design should be further improved [7].
None of the studies comparing ergometrine with expectant management was considered methodologically adequate, and none was conducted in developing countries.
We have also included in the current review the four methodologically adequate formulary interventions not reported in our previous review.
Pairs of independent reviewers extracted the key features and prescribing outcomes of methodologically adequate studies (experiments and strong quasi-experiments).
22– 29 The remaining seven trials fulfilled all selection criteria outlined above and were found to be methodologically adequate.
We extracted key features of the characteristics, methods, and outcomes of methodologically adequate studies using a standardized data extraction tool.
The only methodologically adequate trial (n=55) 71 did not report any clinical relapses during hospitalisation, without longer follow-up.
To our knowledge only few studies have been designed in a (methodologically) adequate way to make any assumptions about this relation [ 77, 79, 80].
Subgroup analyses are presented for methodologically adequate studies, and figures with subgroup summary statistics are presented to demonstrate effects in individual studies and their settings.
Limiting the analyses to studies qualified as methodologically adequate eliminates the heterogeneity, as it reduces the analyses to one study (n = 1000).
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