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The small number of methodologically adequate evaluations of programs means there is limited high-quality evidence that service providers and policy makers can use to improve the effectiveness of programs for high-risk young people.
Consequently, there is a concern whether psychiatric clinical trials are methodologically adequate and, if not, which aspects of trial design should be further improved [7].
None of the studies comparing ergometrine with expectant management was considered methodologically adequate, and none was conducted in developing countries.
We have also included in the current review the four methodologically adequate formulary interventions not reported in our previous review.
The only methodologically adequate trial (n=55) 71 did not report any clinical relapses during hospitalisation, without longer follow-up.
Pairs of independent reviewers extracted the key features and prescribing outcomes of methodologically adequate studies (experiments and strong quasi-experiments).
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In this case benefit assessments were fully declined and not further evaluated even if the indirect comparison was adequate and methodologically correct according to IQWiG (e.g. Linagliptin, Retigabin).
*LD - loading dose In general, there were few methodologically sound studies with adequate sample sizes to definitively determine whether prolonged infusion β-lactams are superior to intermittent infusion β-lactams for the treatment of infections in hospitalized patients.
10 The initial pooled effect size of −0.75 (−0.99 to −0.50) in favour of chondroitin sulphate diminished to zero when the analysis was restricted to methodologically sound trials of adequate sample size.
Implications for future research and practice concern adequate research designs to detect nonlinear relationships; conceptually and methodologically homogeneous studies; differentiated analyses with regard to age, gender, and other characteristics; and greater integration of longitudinal correlational research with (quasi- experimental intervention studies.
Clinical trials, even when most personnel are unblinded, can remain methodologically sound in terms of controlling selection bias through proper randomisation and adequate allocation concealment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com