Their methodological work is motivated by close collaborations with biology groups on problems arising from cancer and developmental biology.
There is a wide variety of prevalence patterns when viewed in this way (Riffe et al.: Time-to-death patterns in markers of age and dependency, forthcoming), (Wolf et al. 2015), and much empirical and methodological work is still required to verify that these findings are representative and to understand the consequences for the standard ways of comparing and projecting HLE.
anyway: already to apply the suggested distinction to a set of futures needs an assessment procedure; making sense of the diversity and divergence of the results of future studies also needs procedures of analysis and assessment – methodological work is needed in several respects.
A cornerstone of our methodological work is the NSF SI2-SSI funded software infrastructure project "ELSI" developed jointly with collaborators around the world to facilitate simple, efficient, and well documented connections of community-based electronic structure codes to massively parallel, high-performance solver libraries for density functional theory.
This suggests that additional methodological work is needed for refining our approach.
A key component of methodological work is the ability to know when a particular method is working well.
Meeting attendance fees for this methodological work were paid to the authors by the National Health and Medical Research Council (NHMRC), a not-for-profit research organisation funded by the Australian Government Department of Health and Ageing.
Future methodological work is needed to examine how to better discriminate between these phases for this task (e.g., decreasing the length of the outcome phase and introducing a jittered inter-trial interval).
The main result of our current methodological work was the introduction of a new, simplified approach to compute predicted values and derive "predicted:observed" ratio of outcomes and assess calibration in validation studies of CPRs.
Several methodological differences with our work are noticeable such as the inclusion of incident and prevalent AED users at cohort entry, the assessment of few individual AEDs rather than AEDs according to enzyme properties, and the lack of adjustment for some potential confounding factors such as smoking or obesity.
