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There are some methodological weaknesses with this study.
A third possible explanation could be methodological weaknesses with the instrument in the sense that the SACS scale might be unsuccessful in capturing relevant staff attitudes.
That study had methodological weaknesses, with electro-cauteric hemostasis (potentially uneven distribution in groups), 5 different types of prostheses, and several surgeons.
None of the few previously published twin studies on hip OA using the CTD seems to relate to the methodological weaknesses with respect to the existence of a common environmental component.
Because of these ambiguities and some methodological weaknesses with the scales, which are beyond the scope of this paper, it is important to elicit directly from individuals with schizophrenia how their experience of the disorder affects their HRQoL.
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We were aware of this and tried to compensate for this methodological weakness with strictly structured measurement procedures where the test leader did not encourage the subjects' performance during the tests.
To avoid the methodological weaknesses associated with before-after studies, no intervention was delivered at hospital 3 for the duration of the study to allow for the estimation of system-wide temporal changes.
In breast cancer survivors, observational studies have consistently reported similar or lower risks for recurrence among women using HT as compared with nonusers [ 7], albeit with methodological weaknesses [ 8]; this has been interpreted as evidence of the safety or perhaps benefit of HT in women with breast cancer.
But the landmark Gissi-Prevenzione trial of fish oil had methodological weaknesses: the patients treated with prescription fish oil pills were compared with untreated patients, rather than with patients given a dummy pill.
Validation studies were small with methodological weaknesses and inconsistent results.
4 5 Included studies were frequently associated with methodological weaknesses that limited the validity of the reported findings.
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Justyna Jupowicz-Kozak
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