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Several methodological weaknesses were identified in the included studies.
Methodological weaknesses were found to relate to such things as questionnaire design, sampling and poor response rates.
Methodological weaknesses were common, including small sample sizes; inadequate study design and short term follow up.
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Some methodological weaknesses are present in this study.
The 14 included studies were generally of average to high quality, with the main methodological weaknesses being use of convenience samples (that is, non-consecutive or selected samples), failure to fully demonstrate the equivalence of the pregnant and not pregnant groups on prognostic indicators before treatment although partial evidence was provided in most included studies), and low power.
Another methodological weakness is the lack of local validation of the scales within the questionnaire, which fell beyond the scope of our study.
However the reviewed studies were limited due to methodological weaknesses and were predominantly undertaken in the US with Latino patients.
From the high number of quality criteria, only the most substantial methodological strengths and weaknesses were reported.
Despite several studies in the current review having methodological weaknesses, there were no major differences in the reporting of participant recruitment by all of the 37 included studies, as compared with those reported by the 11 high-quality studies.
Methodological weaknesses have been outlined in the companion paper, 8 but there are also limitations in this economic.
Although the meta-analysis suggested that SM could have potential therapeutic effects and be relatively safe for chronic cor pulmonale heart failure, a number of inherent and methodological weaknesses should be addressed.
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