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Secondly, we explore methodological issues that may be important when assessing or comparing CAP across countries.

Finally, we explore methodological issues surrounding the development, validation, and comparison of diabetes risk scores.

In this review, we explore the methodological shortcomings of the published clinical studies and describe the criteria that should be considered for performing a definitive clinical trial.

Below we explore three methodological challenges we faced when considering how best to undertake a survey of a system rather than a single service.

Taking user fee exemption policies as an entry point, we explore the methodological consequences of 'complexity' for health policy research and evaluation.

Focusing on the performance of time-dependent density functional theory but using also the ab initio CIS(D), CC2 and CASPT2 methods, we explore how various methodological considerations influence computed spectra and find, somewhat surprisingly, that density functionals lacking exact exchange reproduce the experimental measurements with smaller errors than functionals that include exact exchange.

To identify the most common methodological short-comings, we explored the proportion of articles that met or failed to meet each item separately (Table 2).

Finally, we explored methodological issues surrounding the development, validation and comparison of risk scores.

We explored methodological, statistical and clinical heterogeneity, and built a meta-regression model to explore threshold effects, constructed the Summary Receiver Operating Characteristic (SROC) curves and quantified the impact of study's characteristics on the magnitude of effects, using StatsDirect (v 2.3.7), SPSS (v 11.0.1) and Meta-Disc (v 1.1.0) software.

23 We explored other methodological features through predefined meta-regression.

We explored the association between the methodological reporting quality and center and funding source.

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