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The methodological variability between research teams makes comparisons between studies difficult or nearly impossible.
With this in mind, our approach to identifying genetic factors has sought to extend the linkage mapping approach traditionally applied, to a series of additional traits, while minimising methodological variability between them.
Further limitations included clinical and methodological variability between studies.
Even with minimal methodological variability between the two cohorts, we could not correct for differences in tissue storage and handling.
The main limitations of this review were the small number of included studies as well as the clinical and methodological variability between studies.
Methodological variability between the two groups was minimised by performing TMA construction and IHC staining in the same laboratory and by evaluation of all stainings by the same observers.
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Methodological variability precludes most meaningful comparisons between previous linkage efforts, as studies differ by either the chosen genetic background, prion source, or the host adaptation status of the agent [5].
In contrast to the lack of methodological variability, there were significant differences in ORAC, TP, and TF values between brands of some fruit powders and, in particular, fruit products.
The same methodological variability can be found in the non-Mandarin studies.
However, results also point to substantive and methodological variability in the level of empirical support.
The discrepancy between our results and those obtained in previous studies is not likely to be due to methodological variability.
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