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Details regarding the main methodology characteristics empirically linked to bias 21 were extracted, with the methodological validity of each selected trial assessed by two reviewers (TEAB and OC).
Details regarding the main methodology characteristics empirically linked to bias 24 were extracted, and the methodological validity of each selected trial was assessed by two reviewers (TEAB and OC).
Assessment of the methodological validity of the included studies was performed using criteria adapted from previous reports [30,31].
Supporting the methodological validity of the Blanchard-Katz approach, relative employment growth and relative changes in the activity and unemployment rates tend to oscillate around constant averages.
To assess the methodological validity of the studies included in this review the following aspects were evaluated (according to a binary score presence/absence): randomization, allocation concealment, blinding and description of follow-up.
Methodological validity of the reports was assessed by all authors using the Oxford scale.
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The checklist for methodological validity issues of BCTs, as well as the appraisal of methodological issues inherent to BCTs, was based on the author's previous work with randomized controlled trials and observational studies (8 13), and with methodological issues in RCTs and observational effectiveness studies, including work within the Cochrane Collaboration Back Review Group (1, 9, 12, 14 16).
In order to avoid premature and erroneous conclusions, we have described the importance of valid thresholds for statistical and clinical significance in a systematic review, and we have also described a systematic step-wise methodological approach which will increase the methodological validity and quality of the interpretation of review results.
However, these systematic reviews cannot be considered to provide definitive and compelling support for CCBT due to both the lack of two significant perspectives from clinical implementation and the four issues of methodological validity.
Prospective clinical studies that show methodological validity and clinical relevance of these new techniques in comparison with a standard immunocytochemical assay are, however, needed before PCR-based techniques can be considered for clinical application.
Despite the centrality of health data as part of a coordinated humanitarian response, significant gaps have been highlighted in the methodologies used to collect most kinds of health information in crisis settings, where a lack of appropriately trained field staff who can implement complex study designs and data collection strategies has led to serious concerns of methodological validity [ 6– 9].
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