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There is no current system for identifying methodological trials in progress, until a system is set up it may be useful for systematic review authors to incorporate contacting trials units into their search strategy.
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During the last decades methodological trial quality has improved significantly in many areas of medicine [ 13, 14].
Therefore, our principal aim was to comprehensively evaluate whether the reported methodological quality of trials in Africa differs from that of trials conducted in a better-resourced region of the world, North America.
However, only four low quality trials were eligible for inclusion and the authors concluded there was a need for greater methodological rigour in trials in this area.
The need for further improvement in the methodological quality of trials in physiotherapy for Parkinson's disease was noted in another recent systematic review.
We observed higher methodological quality of trials in our sample compared with a representative sample of trials indexed in PubMed, 44 therefore it could be argued our findings are less likely to be susceptible to confounding by other aspects of trial methodological quality.
Methodological quality measures of trials in meta-analyses have been shown to influence the pooled effect sizes in several medical fields.
To evaluate the convergent and construct validity of the Physiotherapy Evidence Database (PEDro) scale used to rate the methodological quality of randomized trials in physiotherapy.
However, we assume that NI trials retrieved from PubMed do not have different methodological characteristics than NI trials in other databases, so we do not think that this influenced our results.
To our knowledge, our study represents the first comparative analysis of the reporting of methodological quality of clinical trials in resource-rich versus resource-poor parts of the world.
We wished to evaluate the methodological quality of clinical trials in Traditional Chinese Medicine (TCM).
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