Sentence examples for methodological trials from inspiring English sources

There is no current system for identifying methodological trials in progress, until a system is set up it may be useful for systematic review authors to incorporate contacting trials units into their search strategy.

During the last decades methodological trial quality has improved significantly in many areas of medicine [ 13, 14].

Methodological trial quality also undermines review conclusions [ 36, 63], although the majority of trials on which our conclusions rest, were of acceptable quality.

For instance, this analysis was performed on the assumption of consistency where the validity of indirect comparisons was determined by the extent of clinical and methodological trial similarity.

We applied principles from guidelines for conducting systematic reviews and meta-analyses, and included an independent assessment of methodological trial quality by two of the authors.

American investigators had a relative focus on expensive, high methodological strength trials, such as multicenter and phase-type trials.

Methodological considerations Trials with unclear or high risk of bias.

However, evidence is limited as there have been few large methodological strong trials.

To study the effect of methodological quality of trials, we did sensitivity analyses using data from high quality trials only.

Although the methodological quality of trials was variable, the results were in general consistent between the trials of better and poorer quality.

While a placebo-controlled trial in vaccine refusers may be considered, such a trial is unlikely to meet substantial methodological barriers regarding trial size and generalizability.