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During the last decades methodological trial quality has improved significantly in many areas of medicine [ 13, 14].
Methodological trial quality also undermines review conclusions [ 36, 63], although the majority of trials on which our conclusions rest, were of acceptable quality.
We applied principles from guidelines for conducting systematic reviews and meta-analyses, and included an independent assessment of methodological trial quality by two of the authors.
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We next assessed the effect of trial quality on outcome as it is often hypothesized trials of lower methodological quality tend to yield more positive clinical signals for the therapy being tested when compared to trials of higher methodological quality.
We also assessed the effect of trial quality on outcome, as it is often hypothesized that, compared with trials of higher methodological quality, trials of lower methodological quality tend to yield more positive clinical signals for the therapy being tested.
We independently assessed the trials' methodological quality (risk of bias) of each trial, using the Cochrane Collaboration's tool for assessing the risk of bias (Higgins 2011).
Finally, this review did not evaluate yoga's effectiveness or the included trials' methodological quality.
After identifying relevant randomized controlled trials, methodological quality was assessed by using Cochrane tools of bias assessment.
In the interpretation of the results of this meta-analysis, the limited number of available trials, the methodological quality of the included trials and the heterogeneity of the included trials should be noted.
Methodological quality - Trial investigators should describe random sequence allocation, allocation concealment and blinding when reporting trials, as would this would make for greater certainty of conclusions.
Two reviewers independently assessed trial methodological quality and extracted data.
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