Sentence examples for methodological trial from inspiring English sources

During the last decades methodological trial quality has improved significantly in many areas of medicine [ 13, 14].

Methodological trial quality also undermines review conclusions [ 36, 63], although the majority of trials on which our conclusions rest, were of acceptable quality.

For instance, this analysis was performed on the assumption of consistency where the validity of indirect comparisons was determined by the extent of clinical and methodological trial similarity.

We applied principles from guidelines for conducting systematic reviews and meta-analyses, and included an independent assessment of methodological trial quality by two of the authors.

There is no current system for identifying methodological trials in progress, until a system is set up it may be useful for systematic review authors to incorporate contacting trials units into their search strategy.

Despite this the review may be subject to publication bias, although we did not find that trials reporting beneficial results were the methodological weaker trials.

American investigators had a relative focus on expensive, high methodological strength trials, such as multicenter and phase-type trials.

Methodological considerations Trials with unclear or high risk of bias.

However, evidence is limited as there have been few large methodological strong trials.

We independently assessed the trials' methodological quality (risk of bias) of each trial, using the Cochrane Collaboration's tool for assessing the risk of bias (Higgins 2011).

Methodological quality - Trial investigators should describe random sequence allocation, allocation concealment and blinding when reporting trials, as would this would make for greater certainty of conclusions.