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Although methodological studies show that multiple imputation is preferred over complete case analyses and simple imputation methods results from this study should be treated with some caution.
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Albeit the existence of certain methodological differences, both studies show similar dementia comorbidity patterns as the ones obtained here.
The reviewed industry studies show methodological flaws: glyphosate-tolerant GM crops are designed for use with glyphosate herbicide.
However, many of the included studies show methodological limitations and negative results have been reported as well, plausibly reflecting differences in study design, study duration and patients' populations.
Furthermore, the majority of the studies show methodological flaws [ 9].
Some studies show methodological limitations like single centered, non-randomized, a relatively small sample size or no control condition.
Although estimates are highly variable due to methodological challenges, the majority of studies show rates within the range of 3.9 to 8.7 % [ 3, 4, 6, 8, 10– 17].
Furthermore, previous methodological studies have shown that even with high levels of over the counter usage (much higher than is likely to have occurred in our study) valid treatment effects can be obtained using prescription databases [ 25].
Although the estimated metrics may be limited because of the assumptions, methodological studies have shown that AHS participants provide accurate and reliable pesticide use and duration of pesticide exposure information (Blair et al. 2002; Hoppin et al. 2002).
Although recall bias may have influenced responses, methodological studies have shown the quality of information on child diarrhea occurrence reported for a seven-day recall period to be adequate [ 19, 77, 78].
Subgroup analysis according to the methodological quality of randomised studies showed diverse results.
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