Studies have shown that psycho-educational interventions may improve PDwS and primary caregivers' outcomes, but many of the published RCTs have significant methodological shortcomings which limit the comparability of studies and weaken the validity of the conclusions drawn about their effectiveness.
These methodological shortcomings seem to limit the appropriate evaluation of adherence rates for AI treatment, thereby hindering definitive conclusion and accounting for great data variability [ 3, 11].
Many of the included trials, even those rated as at medium risk of bias, had methodological shortcomings that may limit confidence in some of our findings.
The scope of this review was limited to trials that enrolled adult patients with major depressive disorder and compared a second generation antidepressant with CBT, and many of the included trials had methodological shortcomings that may limit confidence in some of the findings.
The evidence, however, is highly limited by practical limitations and methodological shortcomings.
Only regional pilot projects have been evaluated and most of these studies are limited by methodological shortcomings.
Much of the existing data used to implicate environmental agents in ASD is limited by methodological shortcomings and has not addressed the issue of gene environment interactions.
In sum, previous research on early psychological interventions with children after RTAs and other forms of traumatic events is fragmentary, and most studies are limited by methodological shortcomings.
Although PCB exposures in the occupational cohort studies are generally higher than those experienced by the general population, these studies are limited by methodological shortcomings for evaluating NHL risks and a potential lack of applicability to exposures sustained by the general population due to differences in exposure route, dose, metabolism, and congener mixture composition.
The findings of the review were limited by the methodological shortcomings of the included studies.
