Existing reports on prototyping projects merely present their methodological set-up and results, but lack description of the implementation of the methodology.
Building on the methodological set-up developed by Zeintl et al. [8], we measure in this study the activity concentration (ACC) of 99mTc-diphosphono-propanedicarboxylic acid (DPD) in the spongious bone tissue without focal SPECT and CT abnormalities in women referred for bone scintigraphy.
The results confirm that this methodological setting generated useful insights for a finer understanding of energy-consuming practices and their underlying drivers.
Whilst these very short latencies could possibly be due to time delays in the methodological set-up, they could have been movement artefacts on the EMG traces [ 30].
HH contributed to the methodological setting up of diagnostic PCRs and supervised the phylogenetic analyses.
Although it may be easy to identify the function and methodological setting of technology, it can be difficult to pinpoint its organizational aspects.
TO performed the statistical analysis, was responsible for the methodological setting of the study and has written most parts of the manuscript, AB has written some parts of manuscript, AMB is director of the study centre and was the clinical supervisor, PFM conceived and designed the study.
The study was carried out and evaluated according to the following five methodological standards set by Harper et al. (numbering according to Harper et al).
Also, methodological issues set aside, the cost-effectiveness of health technologies might vary from country to country simply due to differences in clinical practice patterns and/or relative prices; hence, extrapolations are not recommended.
At the second stage, two investigators independently reviewed the methods used in the studies selected at the first stage and excluded those that did not meet the methodological standard set by the review.
It uses notoriously exacting methodological standards, setting an acceptable false-positive rate of one in 3.5m (known as the five-sigma standard).
