For methodological rigor, we used a checklist developed by Acquadro et al. [ 60] to design, monitor and document the translation process.
However, there remains a need for evidence of positive learning outcomes from studies using methodological rigor and validated evaluation strategies.
The methodological rigor of primary studies using an assessment tool/scale was conducted by all these reviews except for two [ 18, 19].
The Appraisal of Guidelines for Research and Evaluation (AGREE IIInstrumentnt, an internationally accepted and tested tool was used by all health departments to assess the methodological rigor of practice guidelines [ 43- 45].
Although many investigations of PTSD following critical illness have used methodological rigor, the existing body of work on the subject has a number of significant limitations, as is often the case with early explorations in most arenas.
Furthermore, designing observational studies using high methodological rigor both during the design phase, but also during the analysis phase are needed.
Microbial carotenoid diversity and evolution has hitherto been analyzed primarily from structural and biosynthetic perspectives, with the few phylogenetic analyses of microbial carotenoid biosynthetic proteins using either used limited datasets or lacking methodological rigor.
In particular to this study, one should take into account that the quantitative review was carried out with studies that, although published in a relatively short period of time (from 1986 to 2002), have variation in diagnostic criteria used and have different methodological rigor.
To enhance methodological rigor, a second coder independently analyzed the data using the belief-based concepts generated by the first coder.
However, we draw more detailed and valid conclusions due to our use of improved methodological rigor.
