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Useful methodological results on significance of changes in correlation coefficients can be found in [ 4].
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These data have methodological implications because results on epithelial cells are widely derived from umbilical vein endothelial cells that may not allow the acquisition of reliable data.
Questioning survey results on methodological grounds is a part of the scientific process and can result in healthy debate.
DiMatteo and colleagues [ 13] noted in their review on patient adherence and treatment outcome that the adherence measurement variables of self-report, continuous measures and multi-method approaches moderated the adherence-outcome effects, which again reflects the dependence of results on the methodological approaches used.
The results on the methodological quality of the included studies are presented in text form in Additional file 1 and in a graph in Figure 2. The SEN of the included studies ranged from 0.38 to 0.96, whereas the SPE ranged from 0.64 to 0.98 (forest plots in Figure 3).
Instead of using an arbitrary measure of quality, the actual effect of methodological characteristics on results was tested and then controlled for with regression analysis.
Results on the assessment of the methodological quality of each microarray study are presented in Table 3.
Asking how a new study fits into the context of an entire literature or the effects of methodological choices on results requires considerable expertise and nuance, characteristics which are exemplified by best reporters of science.
An important methodological issue for computational schemes is dependency of numerical results on the used grid size.
One issue is that we based our results on the reports; therefore it is possible that some methodological flaws we encountered were due to lack of reporting.
The main objectives of this study were to review the methodologies of different meta-analyses, assess the impact of specific methodological approaches on efficacy results, and to help interpret previous meta-analyses results concerning the efficacy of memantine in moderate to severe stages of AD.
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CEO of Professional Science Editing for Scientists @ prosciediting.com