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Consequently, further methodological research was needed to build a signal detection algorithm that could account for two, and potentially more, quantified causality criteria at the population level.
A methodological research was conducted on SGRQ in a sample of 240 male patients with COPD recruited from the outpatient services in Central Taiwan.
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Even though the methodological research is in focus here, some general conclusions from our results are drawn in the following.
The implications of the study for applying this framework through mixed methodological research are discussed, alongside an account of the impact of this approach within the NDNIA itself.
We believe that CRM is a good alternative to the standard method from both a statistical and a practical point of view but further methodological research is necessary to address the issues related to the composite nature of the endpoint.
It is unlikely that, in a clinical trial, a single measure will provide the best primary outcome and more methodological research is needed to identify whether longitudinal outcomes, such as rate of change in lung function measures, would be a more appropriate way of assessing lung growth.
It can be concluded that further research, in particular, methodological research, is needed in this field.
Methodological research is underway to investigate the feasibility of their pooling and analysis.
Prospective, randomized, high-quality methodological research is required in order to develop meaningful applicable guidelines.
Additional methodological research is necessary to relax the circular and cylinder assumptions.
Likewise, it is recommended that methodological research is promoted to address the problems still faced with adaptive studies.
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