However, given the stringent methodological requirements in Germany, it will be challenging to obtain an additional benefit on this basis: of the first 23 indirect comparisons submitted after the introduction of AMNOG, only one was formally accepted by the IQWiG [25].
A Go/Nogo task requiring the inhibition of a prepotent response tendency was constructed, in keeping with the methodological requirements used in our previous studies [37] [40].
44 Two other rules, not specifically derived for children, 19 21 have nonetheless been used for validation in a paediatric population, 28 29 32–35 despite the methodological requirement that rules be applied only in populations with the same characteristics as those used in the derivation sets.
In addition, the methodological requirement that no children be included that already receive addiction-specific TAU means that cooperating centres cannot let their "regulars" participate in the groups.
The first methodological requirement to be met is country specific estimates of the EF.
Methodological requirements differed mainly in the acceptance of low-level evidence, surrogate endpoints, and data modeling.
One of the main reasons for the deficiencies in identifying inferior products is the difference in methodological requirements between pharmaceutical and medical devices regarding clinical studies, which serve as a basis for decisions.
At the same time, the different purpose of the assessment process may also explain differences in methodological requirements (e.g. use of modeling).
Some of the discrepancies in terms of methodological requirements between the two HTA systems may, at least in part, be explained by differences in procedural aspects and differences in the robustness of the data assessed at distinct stages of the technology's life cycle.
A concise, integrated comparison follows to highlight the main similarities and differences in the methodological requirements.
